A multiphase Cahn-Hilliard-Darcy model for tumour growth with necrosis
نویسندگان
چکیده
We derive a Cahn–Hilliard–Darcy model to describe multiphase tumour growth taking interactions with multiple chemical species into account as well as the simultaneous occurrence of proliferating, quiescent and necrotic regions. Via a coupling of the Cahn–Hilliard–Darcy equations to a system of reaction-diffusion equations a multitude of phenomena such as nutrient diffusion and consumption, angiogenesis, hypoxia, blood vessel growth, and inhibition by toxic agents, which are released for example by the necrotic cells, can be included. A new feature of the modelling approach is that a volume-averaged velocity is used, which dramatically simplifies the resulting equations. With the help of formally matched asymptotic analysis we develop new sharp interface models. Finite element numerical computations are performed and in particular the effects of necrosis on tumour growth is investigated numerically.
منابع مشابه
On a Cahn--Hilliard--Darcy system for tumour growth with solution dependent source terms
We study the existence of weak solutions to a mixture model for tumour growth that consists of a Cahn–Hilliard–Darcy system coupled with an elliptic reactiondiffusion equation. The Darcy law gives rise to an elliptic equation for the pressure that is coupled to the convective Cahn–Hilliard equation through convective and source terms. Both Dirichlet and Robin boundary conditions are considered ...
متن کاملA Cahn--Hilliard--Darcy model for tumour growth with chemotaxis and active transport
Using basic thermodynamic principles we derive a Cahn–Hilliard–Darcy model for tumour growth including nutrient diffusion, chemotaxis, active transport, adhesion, apoptosis and proliferation. The model generalises earlier models and in particular includes active transport mechanisms which ensure thermodynamic consistency. We perform a formally matched asymptotic expansion and develop several sh...
متن کاملGlobal weak solutions and asymptotic limits of a Cahn--Hilliard--Darcy system modelling tumour growth
We study the existence of weak solutions to a Cahn–Hilliard–Darcy system coupled with a convection-reaction-diffusion equation through the fluxes, through the source terms and in Darcy’s law. The system of equations arises from a mixture model for tumour growth accounting for transport mechanisms such as chemotaxis and active transport. We prove, via a Galerkin approximation, the existence of g...
متن کاملA second order in time, decoupled, unconditionally stable numerical scheme for the Cahn-Hilliard-Darcy system
We propose a novel second order in time, decoupled and unconditionally stable numerical scheme for solving the Cahn-Hilliard-Darcy (CHD) system which models two-phase flow in porous medium or in a Hele-Shaw cell. The scheme is based on the ideas of second order convex-splitting for the Cahn-Hilliard equation and pressure-correction for the Darcy equation. We show that the scheme is uniquely sol...
متن کاملWell-posedness of a Cahn--Hilliard system modelling tumour growth with chemotaxis and active transport
We consider a diffuse interface model for tumour growth consisting of a Cahn– Hilliard equation with source terms coupled to a reaction-diffusion equation. The coupled system of partial differential equations models a tumour growing in the presence of a nutrient species and surrounded by healthy tissue. The model also takes into account transport mechanisms such as chemotaxis and active transpo...
متن کامل